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p-Dok-1 (Y362) pAb

p-Dok-1 (Y362) pAb

Cat no: BS4784


Supplier: Bioworld Technology, Inc.
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Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of
Catalogue number: BS4784
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: Q99704
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Dok-1 around the phosphorylation site of Tyrosine 362.
Species: p-Dok-1 (Y362) pAb detects endogenous levels of Dok-1 protein only when phosphorylated at Tyr362.
Molecular weight: ~ 62 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK1; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62
Additional info: For research use only, not for use in diagnostic procedure.

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