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p-EGFR (S1047) Peptide

Cat no: BS4681P

p-EGFR (S1047) Peptide

EGFR (Epidermal growth factor receptor, ErbB-1) is a receptor tyrosine kinase (RTK) that is one of four members of the EGFR/ErbB family of receptor tyrosine kinases. EGFR plays a key role in the regulation of essential normal cellular processes and in the pathophysiology of hyperproliferative diseases such as cancer. Activation of the EGFR signaling pathway has been linked with increased cell proliferation, angiogenesis, metastasis and decreased apoptosis. EGFR carboxy-terminal residues Ser1046 and Ser1047 are phosphorylated by CaM kinase II; mutation of either of these serines results in upregulated EGFR tyrosine autophosphorylation.

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SPECIFICATIONS

Catalog Number

BS4681P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-EGFR (S1047). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P00533

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS4681 p-EGFR (S1047) pAb.

Alternative Names

Epidermal growth factor receptor; EC=2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1; EGFR

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