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p-ER(alpha) (Y537) pAb

p-ER(alpha) (Y537) pAb

Cat no: BS4683

Supplier: Bioworld Technology, Inc.
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Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER(alpha) and ER(beta), contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus , though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER(alpha) and ER(beta) have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER(alpha) and ER(beta) may be regulated by distinct mechanisms even though they share many functional characteristics.
Catalogue number: BS4683
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P03372
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human ER(alpha) around the phosphorylation site of Tyrosine 537.
Species: p-ER(alpha) (Y537) pAb detects endogenous levels of ER(alpha) protein only when phosphorylated at Tyr537.
Molecular weight: ~ 66 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1
Additional info: For research use only, not for use in diagnostic procedure.

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