p-ErbB2/HER2 (Y1221/Y1222) Peptide

Cat no: BS4089P

Supplier: Bioworld Technology, Inc.

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The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses.

Catalogue number:	BS4089P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P04626
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-ErbB2/HER2 (Y1221/Y1222). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; ERBB2; HER2; MLN19; NEU; NGL
Additional info:	This peptide can be used with studies using BS4089 p-ErbB2/HER2 (Y1221/Y1222) pAb.

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p-ErbB2/HER2 (Y1221/Y1222) Peptide

Cat no: BS4089P

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