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p-Ezrin(T567)/Radixin(T564)/Moesin(T558) pAb

p-Ezrin(T567)/Radixin(T564)/Moesin(T558) pAb

Cat no: BS4717

Supplier: Bioworld Technology, Inc.
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Ezrin, Moesin and Radixin belong to a family of highly homologous Actinassociated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are coexpressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.
Catalogue number: BS4717
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P15311/P26038/P35241
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Ezrin, Radixin, Moesin respectively are around the phosphorylation site of Threonine 567, 564, 558.
Species: p-Ezrin(T567)/Radixin (T564)/Moesin (T558) pAb detects endogenous levels of Ezrin, Radixin and Moesin only when phosphorylated at Thr567, Thr564 or Thr558, respectively.
Molecular weight: ~ 69, 81 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Ezrin; Cytovillin; Villin-2; EZR; VIL2; Moesin; MSN; Radixin; RDX
Additional info: For research use only, not for use in diagnostic procedure.

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