p-Fyn (Y530) pAb

Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is very strongly similar to mouse Fyn, v-yes and c-src. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B cell and T cell activation as well as keratinocyte differentiation. In T cells, Fyn associates with the T-cell antigen receptor and Thy1.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS4076

Size

100ug/100ul

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic phosphopeptide derived from human Fyn around the phosphorylation site of Tyrosine 530.

Species

p-Fyn (Y530) pAb detects endogenous levels of Fyn protein only when phosphorylated at Tyr530.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200\nIP: 1:50~1:200

Swiss Prot

P06241

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~59 kDa

Alternative Names

C syn protooncogene; \nFyn; \nFYN oncogene related to SRC FGR YES; \nFYN; \nMGC45350; \nOKT3 induced calcium influx regulator; \nP59 FYN; \np59-Fyn; \nProtein tyrosine kinase fyn; \nProto oncogene tyrosine protein kinase fyn; \nProto-oncogene c-Fyn; \nProto-oncogene Syn; \nProtooncogene Syn; \nSLK; \nSrc like kinase; \nSrc yes related novel gene; \nSrc-like kinase; \nSrc/yes related novel; \nSrc/yes related novel gene; \nSYN; \nTyrosine kinase p59fyn T; \nTyrosine kinase p59fyn(T); \nTyrosine-protein kinase Fyn; \n