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p-GABAA R(beta)1 (S434) pAb

p-GABAA R(beta)1 (S434) pAb

Cat no: BS4078

Supplier: Bioworld Technology, Inc.
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GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R(alpha)1-6, GABAA R (beta)1-3, GABAA R(gamma)1-3, GABAA R(delta), GABAA RE, GABAA R?1 and GABAA R?2. The GABAB family is composed of GABAB R1(alpha) and GABAB R1(beta). GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
Catalogue number: BS4078
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P18505
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human GABAA R(beta)1 around the phosphorylation site of Serine 434.
Species: p-GABAA R(beta)1 (S434) pAb detects endogenous levels of GABAA R(beta)1 protein when phosphorylated at Ser434.
Molecular weight: ~ 65 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1; GABRB1; GABAAR(beta)1
Additional info: For research use only, not for use in diagnostic procedure.

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