p-GRF-1 (Y1105) Peptide

Cat no: BS4232P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The glucocorticoid receptor (GR) is a ligand-dependent, transactivating regulatory protein that is a member of the nuclear receptor superfamily. GRF-1 (glucocorticoid receptor DNA-binding factor 1), also known as p190RhoGAP or simply p190, is a transcriptional regulator which binds to the promoter region of the glucocorticoid receptor gene and represses its expression. By repressing GR expression, GRF-1 acts to down-regulate Rho signaling, thereby mediating both actin cytoskeletal rearrangements and cell cycle events. Through its GAP domain, GRF-1 is thought to affect cytokinesis by regulating Rho activity; a regulation that is controlled by the ubiquination of the GTP binding region and subsequent degradation of GRF-1. Additionally, GRF-1 plays an important role in oligodendrocyte differentiation, a process that is absent in malignant glioma tumors, implicating GRF-1 as a possible tumor suppressor. GRF-1 expression is regulated by glucocorticoids and the expressed protein exists as two isoforms produced by alternative splicing events.

Catalogue number:	BS4232P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q9NRY4
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-GRF-1 (Y1105) . (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	GRF1; GRLF 1; GRLF1; P190A; p190RhoGAP; KIAA1722;
Additional info:	This peptide can be used with studies using BS4232 p-GRF-1 (Y1105) pAb .

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p-GRF-1 (Y1105) Peptide

Cat no: BS4232P

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