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p-GSK3(alpha)/(beta) (Y279/216) pAb

p-GSK3(alpha)/(beta) (Y279/216) pAb

Cat no: BS4083

Supplier: Bioworld Technology, Inc.
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Glycogen synthase kinase-3 (alpha) and (beta) (GSK-3(alpha), (beta)) are serine/threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3(beta) activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNF(alpha) in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3(alpha) and GSK-3(beta) induces phosphorylation of Ser 21 and Ser 9, respectively through a phosphatidylinositol 3-kinase (PI 3-kinase)-protein kinase B (PKB) dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3(alpha) or Ser 9 of GSK-3(beta) and inactivates both forms
Catalogue number: BS4083
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P49840/P49841
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human GSK3(alpha) around the phosphorylation site of Tyrosine 279.
Species: p-GSK3(alpha)/(beta) (Y279/216) pAb detects endogenous levels of GSK3(alpha)/(beta) protein only when phosphorylated at Tyr279/216
Molecular weight: ~ 46,51 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: GSK3A, DKFZP686D0638, EC 2.7.11.26
Additional info: For research use only, not for use in diagnostic procedure.

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