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p-GSK3(alpha)/(beta) (Y279/216) pAb

Cat no: BS4083

p-GSK3(alpha)/(beta) (Y279/216) pAb

Glycogen synthase kinase-3 (alpha) and (beta) (GSK-3(alpha), (beta)) are serine/threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3(beta) activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNF(alpha) in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3(alpha) and GSK-3(beta) induces phosphorylation of Ser 21 and Ser 9, respectively through a phosphatidylinositol 3-kinase (PI 3-kinase)-protein kinase B (PKB) dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3(alpha) or Ser 9 of GSK-3(beta) and inactivates both forms

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SPECIFICATIONS

Catalog Number

BS4083

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic phosphopeptide derived from human GSK3(alpha) around the phosphorylation site of Tyrosine 279.

Species

p-GSK3(alpha)/(beta) (Y279/216) pAb detects endogenous levels of GSK3(alpha)/(beta) protein only when phosphorylated at Tyr279/216

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P49840/P49841

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 46,51 kDa

Alternative Names

GSK3A, DKFZP686D0638, EC 2.7.11.26

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