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p-HDAC8 (S39) Peptide

Cat no: BS4087P

p-HDAC8 (S39) Peptide

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

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SPECIFICATIONS

Catalog Number

BS4087P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-HDAC8 (S39). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9BY41

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS4087 p-HDAC8 (S39) pAb.

Alternative Names

HDAC8, HD8, HDACL1, RPD3

SUPPLIER INFO

Bioworld Technology, Inc.

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