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p-Histone H2A.X (S139) pAb

p-Histone H2A.X (S139) pAb

Cat no: BS4760


Supplier: Bioworld Technology, Inc.
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H2A.X is a member of the histone H2A family, 1 of 5 families of histone proteins involved in nucleosomal organization of chromatin. H2A.X is synthesised in G1 as well as S phase and is known to be important for recombination between immunoglobulin switch regions. A very early step in the response of mammalian cells to DNA double-strand breaks is the phosphorylation of histone H2A.X at serine 139 at the sites of DNA damage. There is a predicted acetylation at residue 1 and ubiquitination at reside 119. Phosphorylated H2A.X promotes DNA repair and maintains genomic stability.
Catalogue number: BS4760
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P16104
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Histone H2A.X around the phosphorylation site of Serine 139.
Species: p-Histone H2A.X (S139) pAb detects endogenous levels of Histone H2A.X protein only when phosphorylated at Ser139.
Molecular weight: ~ 15 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Histone H2AX; H2a/x; Histone H2A.X; H2AFX; H2AX; (gamma)-H2AX; (gamma)H2AX; ganunaH2AX; (gamma)-H2A.X; (gamma)H2A.X; ganunaH2A.X
Additional info: For research use only, not for use in diagnostic procedure.

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