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p-HNF4(alpha) (S313) pAb

p-HNF4(alpha) (S313) pAb

Cat no: BS4841

Supplier: Bioworld Technology, Inc.
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Hepatocyte nuclear factor 4(alpha) (HNF4(alpha)) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4(alpha), in association with PGC-1(alpha), activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4(alpha) gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4(alpha) have been linked to maturity-onset diabetes of the young (MODY).
Catalogue number: BS4841
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P41235
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human HNF4(alpha) around the phosphorylation site of Serine 313.
Species: p-HNF4-(alpha) (S313) pAb detects endogenous levels of HNF4-(alpha) protein only when phosphorylated at Ser313.
Molecular weight: ~ 52 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: HNF 4 alpha; HNF 4; HNF-4-alpha; HNF4; HNF4A; HNF4A; HNF4a7; HNF4a8; HNF4a9; Hnf4alpha; MODY 1; MODY; MODY1; NR2A1; NR2A21;
Additional info: For research use only, not for use in diagnostic procedure.

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