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p-IkB-(alpha) (Y42) pAb

p-IkB-(alpha) (Y42) pAb

Cat no: BS4736

Supplier: Bioworld Technology, Inc.
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Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase (alpha) (IKK(alpha)), previously designated CHUK, interacts with IkB-(alpha) and specifically phosphorylates IkB-(alpha) on the sites that trigger its degradation Serines 32 and 36. IKK(alpha) appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKK(alpha) is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKK(alpha), IKK(beta) and IKK(gamma) , and each appear to make essential contributions to IkB phosphorylation.
Catalogue number: BS4736
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P25963
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human IkB-(alpha) around the phosphorylation site of Tyrosine 42.
Species: p-IkB-(alpha) (Y42) pAb detects endogenous levels of IkB-(alpha) protein only when phosphorylated at Tyr42.
Molecular weight: ~ 36 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: I kappa B alpha; I kappa B alpha; I(Kappa)B(alpha); I(Kappa)B(alpha); I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA; IKBA; IKBalpha; MAD 3; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBI; NFKBIA; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B c
Additional info: For research use only, not for use in diagnostic procedure.

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