p-IkB-(beta) (S23) pAb

The NF-kB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IkB proteins.The regulation of IkB(beta) and IkBE is similar to that of IkB(alpha). However, the phosphorylation and ubiquitin-mediated degradation of these proteins occurs with much slower kinetics. IKK phosphorylation of IkB(beta) occurs at Ser19 and Ser23, while IkBE can be phosphorylated at Ser18 and Ser22 . The human sequence of IkB-(beta) has also been reported to contain a threonine at position 19 suggesting that phosphorylation could be Thr19/Ser23.

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SPECIFICATIONS

Catalog Number

BS4106

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic phosphopeptide derived from human IkB-(beta) around the phosphorylation site of Serine 23.

Species

p-IkB-(beta) (S23) pAb detects endogenous levels of IkB-(beta) protein only when phosphorylated at Ser23.

Dilutions

WB: 1:500~1:1000\r\nIHC: 1:50~1:200

Swiss Prot

Q15653

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 48 kDa

Alternative Names

I kappa B beta; IKB B; IKB beta; IKBB; IkBbeta; IkappaBbeta; NF kappa B inhibitor beta; NF kappa BIB; NFKBIB; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor beta; TR interacting protein 9; TRIP 9; TRIP9; Thyroid receptor