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p-IkB-E (S22) pAb

p-IkB-E (S22) pAb

Cat no: BS4107

Supplier: Bioworld Technology, Inc.
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IkB-E (I-kappa-B-epsilon), also known as NFKBIE (NFkB inhibitor epsilon) or IKBE, is a 500 amino acid protein that belongs to the NFkB inhibitor family. Localizing to the cytoplasm, IkB-E is highly expressed in spleen, testis and lung, with lower levels of expression found in kidney, pancreas, heart, placenta, brain, granulocytes and macrophages. IkB-E inhibits c-Rel and NFkB subunits p50, p52 and p65 by forming a complex with them in the cytoplasm, preventing them from activating genes in the nucleus. IkB-E undergoes serine phosphorylation, resulting in the protein being marked for destruction via the ubiquitination pathway.
Catalogue number: BS4107
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: O00221
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human IkB-E around the phosphorylation site of Serine 22.
Species: p-IkB-E (S22) pAb detects endogenous levels of IkB-E protein only when phosphorylated at Ser22
Molecular weight: ~ 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: NF-kappa-BIE; I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon; NFKBIE; IKBE; IkB E; IkBE
Additional info: For research use only, not for use in diagnostic procedure.

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