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p-IKK(alpha)/(beta) (S180/181) pAb

p-IKK(alpha)/(beta) (S180/181) pAb

Cat no: BS4237

Supplier: Bioworld Technology, Inc.
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The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKK(alpha) and IKK(beta) serve as the catalytic subunits of the kinase and IKK(gamma) serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKK(beta) (Ser176 and Ser180 in IKK(alpha)), which causes conformational changes, resulting in kinase activation.
Catalogue number: BS4237
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: O15111/O14920
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human IKK(alpha)/(beta) around the phosphorylation site of Serine 180/181.
Species: p-IKK(alpha)/(beta) (S180/181) pAb detects endogenous levels of IKK(alpha) only when phosphorylated at Ser180 and IKK(beta) only when phosphorylated at Ser181.
Molecular weight: ~ 85 kDa (IKK(alpha)); 87kDa (IKK(beta))
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; EC 2.7.11.10; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; CHUK; IKKA; TCF16
Additional info: For research use only, not for use in diagnostic procedure.

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