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p-IKK(beta) (Y199) pAb

p-IKK(beta) (Y199) pAb

Cat no: BS4320

Supplier: Bioworld Technology, Inc.
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The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylate on specific serine residues, which results in targeted degradation of IkB. IkB kinase (alpha) (IKK(alpha)), previously designated CHUK, interacts with IkB-(alpha) and specifically phosphorylates IkB-(alpha) on Serines 32 and 36, the sites that trigger its degradation. IKK(alpha) appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKK(alpha) is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulato for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKK(alpha), IKK(beta) and IKK(gamma) (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.
Catalogue number: BS4320
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: O14920
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human eEF2K around the phosphorylation site of Tyrosine 199.
Species: p-IKK(beta) (Y199) pAb detects endogenous levels of IKK(beta) protein only when phosphorylated at Tyr199.
Molecular weight: ~ 86 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Inhibitor of nuclear factor kappa B kinase beta subunit; I-kappa-B-kinase beta; IkBKB; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB
Additional info: For research use only, not for use in diagnostic procedure.

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