p-IKKalpha/beta (S180/181) Peptide

Cat no: BS4237P

Supplier: Bioworld Technology, Inc.

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The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins. Most agents that activate NF-kB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IkB. The key regulatory step in this pathway involves activation of a high molecular weight IkB kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKalpha and IKKbeta serve as the catalytic subunits of the kinase and IKKgamma serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKbeta (Ser176 and Ser180 in IKKalpha), which causes conformational changes, resulting in kinase activation.

Catalogue number:	BS4237P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O15111/O14920
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-IKKalpha/beta (S180/181). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; EC 2.7.11.10; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; CHUK; IKKA; TCF16
Additional info:	This peptide can be used with studies using BS4237 p-IKKalpha/beta (S180/181) pAb.

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p-IKKalpha/beta (S180/181) Peptide

Cat no: BS4237P

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