p-IKKbeta (Y199) Peptide

Cat no: BS4320P

Supplier: Bioworld Technology, Inc.

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The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylate on specific serine residues, which results in targeted degradation of IkB. IkB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on Serines 32 and 36, the sites that trigger its degradation. IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKalpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulato for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

Catalogue number:	BS4320P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	O14920
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p-IKKbeta (Y199). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Inhibitor of nuclear factor kappa B kinase beta subunit; I-kappa-B-kinase beta; IkBKB; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB
Additional info:	This peptide can be used with studies using BS4320 p-IKKbeta (Y199) pAb.

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p-IKKbeta (Y199) Peptide

Cat no: BS4320P

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