p-IKKgamma (S85) Peptide

Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase alpha (IKKalpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates I?Balpha on Serine 32 and 36, the sites that trigger its degradation. IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKalpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKalpha, IKKbeta and IKKgamma (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

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SPECIFICATIONS

Catalog Number

BS4597P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-IKKgamma (S85). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9Y6K9

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS4597 p-IKKgamma (S85) pAb.

Alternative Names

NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier; IKBKG; FIP3; NEMO; IKK-gamma