p-IL-3R(beta) (Y593) pAb

Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific (alpha) subunit (IL-3R(alpha)) and a signal transducing (beta) subunit (IL-3R(beta)) common to the IL-3/IL-5/GM-CSF receptors. The (alpha) subunits are low-affinity ligand-binding proteins while the (beta) subunits do not themselves bind ligand, but are required for high affinity binding by the (alpha) subunits. The mouse IL-3 receptor has two distinct (beta) subunits, one that functions only in IL-3-mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine (beta) subunits are 91% homologous at the amino acid level but only 56% homologous to the human (beta) subunit.

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SPECIFICATIONS

Catalog Number

BS4102

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic phosphopeptide derived from human IL-3R(beta) around the phosphorylation site of Tyrosine 593.

Species

p-IL-3R(beta) (Y593) pAb detects endogenous levels of L-3R protein only when phosphorylated at Tyr593.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P32927

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul