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p-Insulin Receptor (Y1355) pAb

p-Insulin Receptor (Y1355) pAb

Cat no: BS4270


Supplier: Bioworld Technology, Inc.
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The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular (beta) subunit and an extracellular (alpha) subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.
Catalogue number: BS4270
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P06213
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1355.
Species: p-Insulin Receptor (Y1355) pAb detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1355.
Molecular weight: ~ 95 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: CD 220; CD220; CD220 antigen; HHF 5; HHF5; human insulin receptor; INSR; INSR; Insulin receptor subunit beta; IR 1; IR; IR-1; IR1;
Additional info: For research use only, not for use in diagnostic procedure.

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