p-IPP2 (S120/S121) Peptide

Two inhibitors of protein phosphatase 1 (PP1) include the phosphatase inhibitor 1 (IPP-1) and phosphatase inhibitor 2 (IPP-2) . IPP-2, also known as I-2, interacts with the catalytic subunit of PP1 to form the heterodimer PP1I. The PP1I complex is present in the cytosol of cells in a broad range of vertebrate and invertebrate species. Although the heterodimer itself is inactive, a reversible phosphorylation of IPP-2 at Thr 72 by glycogen-synthase-kinase (GSK3) initiates activation of the heterodimer complex in vitro. Phosphorylation of IPP-2 by casein kinase-II at Ser 86, Ser 120, and Ser 121 enhances the rate of phosphorylation by GSK3 at Thr 72 and effectively activates the heterodimer complex. Besides moderating PP1 activity, IPP-2 may play a role as a chaperone for the correct folding of PP1.

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SPECIFICATIONS

Catalog Number

AP0341P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-IPP2 (S120/S121). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P41236

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using AP0341 p-IPP2 (S120/S121) pAb.

Alternative Names

IPP 2; IPP-2; IPP2; IPP2; MGC87148; Phosphatase inhibitor 2; Phosphoprotein phosphatase; Ppp1r2; PPP1R2 protein; Protein phosphatase 1 regulatory (inhibitor) subunit 2; Protein phosphatase 1 regulatory subunit 2; Protein phosphatase inhibitor 2;