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p-IRAK1 (T209) pAb

p-IRAK1 (T209) pAb

Cat no: BS4698

Supplier: Bioworld Technology, Inc.
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Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1(alpha) and IL-1(beta), and a specific receptor antagonist, IL-1R(alpha). Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFkB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFkB.
Catalogue number: BS4698
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P51617
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Threonine 209.
Species: p-IRAK1 (T209) pAb detects endogenous levels of IRAK1 protein only when phosphorylated at Thr209.
Molecular weight: ~ 76 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK1; IRAK
Additional info: For research use only, not for use in diagnostic procedure.

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