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p-IRF-3 (S385) Peptide

p-IRF-3 (S385) Peptide

Cat no: BS4609P

Supplier: Bioworld Technology, Inc.
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IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKKE and TBK1. IRF-3 is phosphorylated at Ser396 following viral infection, expression of viral nucleocapsid, and double-stranded RNA treatment. These events likely play a role in activation of IRF-3.
Catalogue number: BS4609P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q14653
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-IRF-3 (S385). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: IRF3, IRF-3, IRF3, Interferon regulatory factor 3
Additional info: This peptide can be used with studies using BS4609 p-IRF-3 (S385) pAb.

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