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p-IRS-1 (S612) Peptide

Cat no: BS5084P

p-IRS-1 (S612) Peptide

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.

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SPECIFICATIONS

Catalog Number

BS5084P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-IRS-1 (S612). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P35568

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS5084 p-IRS-1 (S612) pAb.

Alternative Names

Insulin receptor substrate 1; IRS-1; IRS1

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