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p-JAK1 (Y1022) Peptide

Cat no: BS4108P

p-JAK1 (Y1022) Peptide

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

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SPECIFICATIONS

Catalog Number

BS4108P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-JAK1 (Y1022). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P23458

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS4108 p-JAK1 (Y1022) pAb.

Alternative Names

AA960307; C130039L05Rik; JAK1A; JAK1B; Janus kinase 1; Janus kinase 1a. Entrez Gene ID: 3716

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