p-JAK2 (Y570) pAb

Cat no: BS4610

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.

Catalogue number:	BS4610
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug/100ul
Swiss prot:	O60674
Dilutions:	WB: 1:500~1:1000
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 570.
Species:	p-JAK2 (Y570) pAb detects endogenous levels of JAK2 only when phosphorylated at Tyr570.
Molecular weight:	~ 125 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	JAK 2; JAK-2; JAK2; Janus Activating Kinase 2; Janus Kinase 2; Janus Kinase 2; JTK 10; JTK10;
Additional info:	For research use only, not for use in diagnostic procedure.

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p-JAK2 (Y570) pAb

Cat no: BS4610

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