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p-mTOR (S2448) pAb

p-mTOR (S2448) pAb

Cat no: BS4706

Supplier: Bioworld Technology, Inc.
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mTOR, or FKBP12-rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Catalogue number: BS4706
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P42345
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human mTOR around the phosphorylation site of Serine 2442.
Species: p-mTOR (S2448) pAb detects endogenous levels of mTOR protein when phosphorylated at Ser2448.
Molecular weight: ~ 289 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; Rapamycin target protein; RAPT1; Mammalian target of rapamycin; mTOR; mTOR; FK506 binding protein12-rapamycin associated protein 1. FK506 binding protein12-ra
Additional info: For research use only, not for use in diagnostic procedure.

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