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p-Nibrin (S343) pAb

p-Nibrin (S343) pAb

Cat no: BS4153

Supplier: Bioworld Technology, Inc.
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The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex (MRN complex). This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions. In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells. NBS1 is expressed ubiquitously and presents high levels in testis.
Catalogue number: BS4153
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O60934
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Nibrin around the phosphorylation site of Serine 343.
Species: p-p95/NBS1 (S343) pAb detects endogenous levels of p95/NBS1 protein when phosphorylated at Ser343.
Molecular weight: ~ 95 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Nijmegen breakage syndrome protein 1; Cell cycle regulatory protein p95; NBS1/P95; NBS; NBS1; P95
Additional info: For research use only, not for use in diagnostic procedure.

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