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p-PI3K p85(beta) (Y464) pAb

p-PI3K p85(beta) (Y464) pAb

Cat no: BS4811

Supplier: Bioworld Technology, Inc.
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Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85(alpha) and p85(beta)), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110(alpha) and p110(beta) interact with p85(alpha), and p110(alpha) has also been shown to interact with p85(beta) in vitro. p110(delta) expression is restricted to white blood cells. It has been shown to bind p85(alpha) and p85(beta), but it apparently does not phosphorylate these subunits. p110(delta) seems to have the capacity to autophosphorylate. p110(gamma) does not interact with the p85 subunits. It has been shown to be activated by (alpha) and (beta)(gamma) heterotrimeric G proteins.
Catalogue number: BS4811
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O00459
Dilutions: WB: 1:500~1:1009
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human PI3K p85(beta) around the phosphorylation site of Tyrosine 464.
Species: p-PI 3-kinase p85(beta) (Y464) pAb detects endogenous levels of PI 3-kinase p85(beta) protein when phosphorylated at Tyr464.
Molecular weight: ~ 85 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: p85; p85 beta; P85B; P85B; Phosphatidylinositol 3 kinase; Phosphatidylinositol 3 kinase regulatory beta subunit; Phosphatidylinositol 3 kinase regulatory subunit beta; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2; Phosphatidylinositol 3 kinase; regulatory subunit; polypeptide 2 (p85 beta); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Phosphatidylinositol 3-kinase regulatory subunit beta; Phosphoinositide 3 kinase regulatory subunit 2 (beta); P
Additional info: For research use only, not for use in diagnostic procedure.

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