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p-PKR (T446) pAb

p-PKR (T446) pAb

Cat no: BS4789

Supplier: Bioworld Technology, Inc.
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An interferon-inducible, RNA-dependent protein serine/threonine kinase (PKR) has been described. PKR in earlier literature is variously known as DAI, dsJ, PI kinase, p65, p67 or TIK for the mouse kinase; and p68 or p69 for the human kinase. The PKR kinase substrate is the (alpha) subunit of protein synthesis initiation factor eIF-2. Phosphorylation of eIF-2(alpha) on serine-51 results in inhibition of translation. Molecular cDNA clones have been isolated from both human and mouse cells. The serine/threonine kinase catalytic domains map to the carboxy terminal half of the protein while the RNA-binding domains are located in the amino terminal region. Three kinds of regulation of PKR enzymatic activity have been described.
Catalogue number: BS4789
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P19525
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human PKR around the phosphorylation site of Threonine 446.
Species: p-PKR (T446) pAb detects endogenous levels of PKR protein only when phosphorylated at Thr446.
Molecular weight: Predicted band size : 62 kDa Observed band size : 68 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein kinase; Protein kinase RNA-activated; PKR; Tyrosine-protein kinase EIF2AK2; p68 kinase; PKR; PRKR; EIF2AK2
Additional info: For research use only, not for use in diagnostic procedure.

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