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p-PLC (beta)3 (S537) pAb

p-PLC (beta)3 (S537) pAb

Cat no: BS4864

Supplier: Bioworld Technology, Inc.
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A total of eight mammalian PLC isozymes have been described (PLC (beta)1, PLC (beta)2, PLC (beta)3, PLC (beta)4, PLC (gamma)1, PLC (gamma)2, PLC (delta)1 and PLC (delta)2) with molecular weights ranging from 85 to 150 kDa. The (gamma)-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two (gamma)-type enzymes, but not the (beta) and (delta) isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC (beta)1, PLC (beta)2 and PLC (beta)3 is mediated by the (alpha) subunits of the Gq class of heterotrimeric G proteins and by certain (beta)(gamma) G protein subunits. The regulatory mechanisms for PLC (delta)1 and PLC (delta)2 are as yet not resolved.
Catalogue number: BS4864
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q01970
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human PLC (beta)3 around the phosphorylation site of Serine 537.
Species: p-PLC (beta)3 (S537) pAb detects endogenous levels of PLC (beta)3 protein only when phosphorylated at Ser537.
Molecular weight: ~ 150 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (beta)-3; Phosphoinositide phospholipase C-(beta)-3; Phospholipase C-(beta)-3; PLC-(beta)3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3; PLCB3; PLC(beta)3
Additional info: For research use only, not for use in diagnostic procedure.

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