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p-PP2A-(alpha) (Y307) pAb

p-PP2A-(alpha) (Y307) pAb

Cat no: BS4867

Supplier: Bioworld Technology, Inc.
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In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. The PP2A family comprises subfamily members PP2A(alpha) and PP2A(beta). An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family.
Catalogue number: BS4867
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P67775
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human PP2A-(alpha) around the phosphorylation site of Tyrosine 307.
Species: p-PP2A-(alpha) (Y307) pAb detects endogenous levels of PP2A-(alpha) protein only when phosphorylated at Tyr307.
Molecular weight: ~ 38 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C; PPP2CA; PP2A(alpha); PP2A (alpha)
Additional info: For research use only, not for use in diagnostic procedure.

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