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p-PR/PGR (S294) Peptide

p-PR/PGR (S294) Peptide

Cat no: BS4868P

Supplier: Bioworld Technology, Inc.
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The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen inducible promoters within a single copy of the PR gene. The PR-A and PR-B proteins are 90 kDa and 118 kDa respectively; the first 164 amino acids of PR-B are absent in PR-A. Progesterone bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand dependent transdominant repressor of steroid hormone receptor transcriptiona activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms.
Catalogue number: BS4868P
Applications: Block/Neutralize/Inhibit
Swiss prot: P06401
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-PR/PGR (S294). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: NR3C3; PGR; PRGR; Progesterone receptor
Additional info: This peptide can be used with studies using BS4868 p-PR/PGR (S294) pAb.

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