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p-Rad17 (S645) pAb

p-Rad17 (S645) pAb

Cat no: BS4248

Supplier: Bioworld Technology, Inc.
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DNA damage results in the arrest of cell cycle progression, allowing the damaged DNA to be repaired prior to replication. Checkpoints exist at several cell cycle phase transitions to maintain this genetic integrity. Rad9, Rad17, Rad24 and Mec3 are involved in activating the G1 and G2 checkpoints. Pol2 (also known as Dun2), encoding the catalytic subunit of DNA polymerase epsilon, plays a role in activating the S phase checkpoint. The protein kinase Rad53 (also designated Spk1, Mec2 or Sad1) is essential for both G2 and S phase arrest. Activation of Rad53 is regulated by Mec1 (also known as Esr1 and Sad3), a homolog of the human ATM protein. Pds1 and Mad2 both regulate checkpoints associated with incomplete spindle replication. Dun1, another protein kinase, plays a role in transducing the DNA damage signal. The phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.
Catalogue number: BS4248
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: O75943
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Rad17 around the phosphorylation site of Serine 645.
Species: p-Rad17 (S645) pAb detects endogenous levels of Rad17 protein when phosphorylated at Ser645.
Molecular weight: ~ 80 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: CCYC; Cell cycle checkpoint protein; Cell cycle checkpoint protein RAD17; HRAD 17; HRAD17; R24L; Rad 17; Rad 24; RAD1 (S. pombe) homolog; RAD17; RAD17 homolog; Rad17 like protein; RAD17; RAD17Sp; Rad24; RF C activator 1 homolog; RF C/activator 1 homolog; RF-C/activator 1 homolog
Additional info: For research use only, not for use in diagnostic procedure.

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