p-Rpb1 (S1619) pAb

RPB1 is a subunit of RNA polymerase II which catalyses transcription of RNA from DNA. RPB1 forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.

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SPECIFICATIONS

Catalog Number

BS4246

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic phosphopeptide derived from human Rpb1 around the phosphorylation site of Serine 1619.

Species

p-Rpb1 (S1619) pAb detects endogenous levels of Rpb1 protein only when phosphorylated at Ser1619.

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P24928

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

217,240 kDa

Alternative Names

DNA directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase II largest subunit; hRPB220; hsRPB1; MGC75453; POLR2; POLR2A; POLRA; Polymerase (RNA) II (DNA directed) polypeptide A 220kDa; polymerase (RNA) II (DNA directed) polypeptide A; 220kDa; RNA polymerase II subunit 1; RNA polymerase II subunit B1; RP02; RPB220; RPBh1; RpIILS; RPO21; RPOL2; SUA8;