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p-Shb (Y246) pAb

p-Shb (Y246) pAb

Cat no: BS4821

Supplier: Bioworld Technology, Inc.
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The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosinephosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf(SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell.
Catalogue number: BS4821
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q15464
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Shb around the phosphorylation site of Tyrosine 246.
Species: p-Shb (Y246) pAb detects endogenous levels of Shb protein only when phosphorylated at Tyr246.
Molecular weight: ~55kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: SH2 domain-containing adapter protein B; SHB
Additional info: For research use only, not for use in diagnostic procedure.

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