p-SHP-2 (Y580) pAb

Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

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SPECIFICATIONS

Catalog Number

BS4171

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 580.

Species

p-SHP-2 (Y580) pAb detects endogenous levels of SHP-2 protein only when phosphorylated at Tyr580

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

Q06124

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~70 kDa

Alternative Names

PTP 1D , PTP 2C , PTP-1D , PTP-2C , PTP1D , PTP2C , PTPN 11 , PTPN11 , PTPN11 , SAP2 , SH PTP2 , SH PTP3 , SH-PTP2 , SH-PTP3 , SH2 domain containing protein tyrosine phosphatase 2 , SHIP2 , SHP 2 , SHP-2 , Shp2 , SHPTP 2 , SHPTP2 , SHPTP3 ,