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p-Stat3 (Y705) Peptide

p-Stat3 (Y705) Peptide

Cat no: AP0247P

Supplier: Bioworld Technology, Inc.
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Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-alpha and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3beta appears to be activated by both while Stat3alpha is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Catalogue number: AP0247P
Applications: Block/Neutralize/Inhibit
Swiss prot: P40763
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p-Stat3 (Y705). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: 1110034C02Rik; Acute Phase Response Factor; Acute-phase response factor; APRF; APRF; AW109958; DNA binding protein APRF; FLJ20882; HIES; MGC128731; MGC16063; MGC93551; Signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and activator of transcription 3; Signal Transductor and Activator of Transcription 3; Signal Transductor and Activator of Transcription 3; STAT 3; Stat3; STAT3; Transcription factor;
Additional info: This peptide can be used with studies using AP0247 p-Stat3 (Y705) pAb.

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