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p-Synaptotagmin 1/2 (T202/199) pAb

p-Synaptotagmin 1/2 (T202/199) pAb

Cat no: BS4191


Supplier: Bioworld Technology, Inc.
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Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
Catalogue number: BS4191
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P21579/Q8N9I0
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human Synaptotagmin 1 around the phosphorylation site of Threonine 202.
Species: p-Synaptotagmin 1/2 (T202/199) pAb detects endogenous levels of Synaptotagmin 1/2 protein only when phosphorylated at SerT202/199.
Molecular weight: ~ 60 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; SYT; SYT1; SYT2; SytI; SytII;
Additional info: For research use only, not for use in diagnostic procedure.

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