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p-Synuclein-(alpha) (Y133) pAb

p-Synuclein-(alpha) (Y133) pAb

Cat no: BS4772

Supplier: Bioworld Technology, Inc.
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The synuclein family members, including (alpha)-synuclein (also designated NACP for non-(beta) Amyloid component) and (beta)-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. (alpha)-synuclein is localized to neuronal cell bodies and synapses. (alpha)-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation (alpha)-synuclein has been found to be upregulated, while (beta)-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of (alpha)-synuclein has been found in patients with early onset Parkinson's disease.
Catalogue number: BS4772
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P37840
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 120-160 of Human Synuclein-(alpha).
Species: p-Synuclein-(alpha) (Y133) pAb detects endogenous levels of Synuclein-(alpha) protein only when phosphorylated at Tyr133
Molecular weight: ~ 18 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Alpha synuclein , Alpha-synuclein , Alpha-synuclein, isoform NACP140 , alphaSYN , PARK 1 , PARK 4 , PARK1 , PARK4 , Parkinson disease (autosomal dominant, Lewy body) 4 , Parkinson disease familial 1 , PD 1 , PD1 , SNCA , Snca synuclein, alpha (non A4 component of amyloid precursor) , Synuclein alpha 140 , Synuclein alpha ,
Additional info: For research use only, not for use in diagnostic procedure.

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