p-Synuclein-(alpha) (Y133) pAb

The synuclein family members, including (alpha)-synuclein (also designated NACP for non-(beta) Amyloid component) and (beta)-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. (alpha)-synuclein is localized to neuronal cell bodies and synapses. (alpha)-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation (alpha)-synuclein has been found to be upregulated, while (beta)-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of (alpha)-synuclein has been found in patients with early onset Parkinson's disease.

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SPECIFICATIONS

Catalog Number

BS4772

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 120-160 of Human Synuclein-(alpha).

Species

p-Synuclein-(alpha) (Y133) pAb detects endogenous levels of Synuclein-(alpha) protein only when phosphorylated at Tyr133

Dilutions

WB: 1:500~1:1000\nIHC: 1:50~1:200

Swiss Prot

P37840

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 18 kDa

Alternative Names

Alpha synuclein , Alpha-synuclein , Alpha-synuclein, isoform NACP140 , alphaSYN , PARK 1 , PARK 4 , PARK1 , PARK4 , Parkinson disease (autosomal dominant, Lewy body) 4 , Parkinson disease familial 1 , PD 1 , PD1 , SNCA , Snca synuclein, alpha (non A4 component of amyloid precursor) , Synuclein alpha 140 , Synuclein alpha ,