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p-Vav (Y174) pAb

p-Vav (Y174) pAb

Cat no: BS4204

Supplier: Bioworld Technology, Inc.
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The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. Contained within its amino terminus are a helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins; deletion of this region of p95Vav causes its oncogenic activation. In addition, p95Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of p95Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages.
Catalogue number: BS4204
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P15498
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic phosphopeptide derived from human VaV1 around the phosphorylation site of Tyrosine 174.
Species: p-Vav (Y174) pAb detects endogenous levels of Vav protein when phosphorylated at Tyr174.
Molecular weight: ~ 100 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Flk - 1 / KDR / VEGFR2; VEGFR-2; EC 2.7.10.1; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen; VEGFR2; 16542; Kdr; 6130401C07; Flk-1; Flk1; Krd-1; Ly73; VEGFR-2; VEGFR2; 3791; KDR; 191306; P35
Additional info: For research use only, not for use in diagnostic procedure.

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