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p300 (E83) Peptide

Cat no: BS1562P

p300 (E83) Peptide

Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A, bind to this element. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.

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SPECIFICATIONS

Catalog Number

BS1562P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p300 (E83). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q09472

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1562 p300 (E83) pAb.

Alternative Names

p300; p300 HAT; EC 2.3.1.48; E1A-associated protein p300; p300; P300

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