p300 (E83) Peptide

Cat no: BS1562P

Supplier: Bioworld Technology, Inc.

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Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A, bind to this element. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.

Catalogue number:	BS1562P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q09472
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p300 (E83). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	p300; p300 HAT; EC 2.3.1.48; E1A-associated protein p300; p300; P300
Additional info:	This peptide can be used with studies using BS1562 p300 (E83) pAb.

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p300 (E83) Peptide

Cat no: BS1562P

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