p35 (Q31) Peptide

Cyclin dependent kinase-5 (Cdk5), a key regulator of cell cycle progression, was originally isolated on the basis of its structural homology to Cdc2, a wellcharacterized regulator of cell cycle progression. Although Cdk5 is expressed at the highest level in the brain of adult mice, intermediate levels in testis and low or undetectable levels in all other tissues, brain is the only tissue from which Cdk5 can be isolated as an active kinase. These findings may be explained by the cloning and characterization of a Cdk5 regulatory subunit, designated p35. p35 displays a neuronal cell-specific pattern of expression, physically associates with Cdk5 and activates Cdk5 enzymatic activity. p35 is also expressed in many tissues in a truncated form, designated p25.

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SPECIFICATIONS

Catalog Number

BS2065P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p35 (Q31). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q15078

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2065 p35 (Q31) pAb.

Alternative Names

Cyclin-dependent kinase 5 activator 1 [Precursor]; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; Tau protein kinase II 23 kDa subunit; p23; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1; p35; Cyclin-dependent kin