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p39 (N100) Peptide

p39 (N100) Peptide

Cat no: BS2044P

Supplier: Bioworld Technology, Inc.
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Cyclin dependent kinases, known as Cdks, regulate transitions in the eukaryotic cell cycle. Cdk 5 is required for proper development of the mammalian central nervous system and is predominantly expressed in neurons. Neuronal Cdk5 can be activated by two accessory proteins designated p35nck5a and p39nck5ai, which is also known as p39. The human p39 gene maps to chromosome 2q35 and encodes a 367-amino acid, 39 kDa protein. p35 and p39 both share limited similarity to cyclins and may define a distinct family of cyclin-dependent kinase activating proteins. During embryonic rat brain development, the expression pattern of p39 appears to have an inverse relationship to that of Cdk5 and p35, suggesting that these proteins may have region-specific and developmental stage-specific functions in rat brain. p39 can localize to lamellipodial and fillopodial structures of cells and in growth cones of neurons. In addition, p39 can colocalize with actin, suggesting that p39 plays a role in regulating actin cytoskeletal dynamics in cells. The temporal and spatial expression of p39 in synaptic junctions indicates a possible role of the p39/cdk5 kinase at the synapse.
Catalogue number: BS2044P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q13319
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide p39 (N100). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Cyclin-dependent kinase 5 activator 2 [Precursor]; CDK5 activator 2; Cyclin-dependent kinase 5 regulatory subunit 2; P39; P39I; CDK5R2; NCK5AI
Additional info: This peptide can be used with studies using BS2044 p39 (N100) pAb.

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