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p53 (C-terminus) mAb

p53 (C-terminus) mAb

Cat no: MB0038

Supplier: Bioworld Technology, Inc.
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p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation.
Catalogue number: MB0038
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: P04637
Dilutions: WB: 1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the C-terminus of Human p53.
Species: This antibody detects endogenous levels of p53 (C-terminus) and does not cross-react with related proteins
Molecular weight: Predicted band size:53KDa Observed band size:53KDa
Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53
Additional info: For research use only, not for use in diagnostic procedure.

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