p57 (S306) Peptide

Cat no: BS1683P

Supplier: Bioworld Technology, Inc.

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p57 / Kip 2 (or CDKN 1C) is a potent tight binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57 / Kip 2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith Wiedemann syndrome (BWS, a cancer syndrome) making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin like growth factor II (IGF II) and H19, both of which seem to be implicated in adrenal neoplasms.

Catalogue number:	BS1683P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	P49918
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide p57 (S306). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57Kip2; WBS;
Additional info:	This peptide can be used with studies using BS1683 p57 (S306) pAb.

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p57 (S306) Peptide

Cat no: BS1683P

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