p63 (N662) pAb

Cat no: BS1279

Supplier: Bioworld Technology, Inc.

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The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. p73 shares a high degree of homology with p53, and appears to have similar growth-inhibiting and apoptosis-promoting functions. However, unlike p53, the expression of p73 is not upregulated in response to DNA damage. p73 can, when overproduced, activate the p53- responsive gene p21. p63 has also been identified based on its similarities with p53. The p63 gene encodes multiple isotypes with variable functions. p63(alpha) (also designated p51B or KET), p63(beta) and p63(gamma) (also designated p51A), as well as corresponding TA* p63 isoforms, contain transactivation domains which have been shown to transactivate p53 reporter genes and induce apoptosis. p63 isoforms lack the transactivation domain and can act as dominant- negative reagents to inhibit transactivation by p53 and p63.

Catalogue number:	BS1279
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q9H3D4
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 634-680 of Human p63.
Species:	p63 (N662) pAb detects endogenous levels of p63 protein.
Molecular weight:	~ 77 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L;
Additional info:	For research use only, not for use in diagnostic procedure.

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p63 (N662) pAb

Cat no: BS1279

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