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PAK1/2/3 (E417) Peptide

PAK1/2/3 (E417) Peptide

Cat no: BS1570P

Supplier: Bioworld Technology, Inc.
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Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gamma PAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gamma PAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gamma PAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gamma PAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
Catalogue number: BS1570P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q13153/Q13177/O75914
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide PAK1/2/3 (E417). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Serine/threonine-protein kinase PAK 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK; PAK1; PAKalpha; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58; PAK-2p27; PAK-2p34; C-t-PAK2; PAK2; PAKgamma ; Serine/threonine-protein kinase PAK 3; Beta-PAK; Oligophrenin-3; p21-activated kinase 3; PAK-3; PAK3; OPHN3; PAKbeta;
Additional info: This peptide can be used with studies using BS1570 PAK1/2/3 (E417) pAb.

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